Amiloride
Amiloride
Definition
A synthetic pyrazine derivative with antikaliuretic and diuretic properties. Amiloride inhibits sodium channels located in the distal tubules and collecting ducts of the kidney, thereby preventing the absorption of sodium and increasing its excretion along with water, to produce naturesis. In response to the hypernatremic conditions in the kidney, the plasma membrane becomes hyperpolarized and electrochemical forces are reduced, which then prevents the excretion of potassium and hydrogen into the lumen.
Also known as AMILORIDE — per NCIT
Also identified as
- ATC C03DB01 per RXNORM
- NCIT NCIT:C61633 per NCIT
- SCTID 387503008 per RXNORM
- SCTID 87395005 per RXNORM
- UNII 7DZO8EB0Z3 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Potassium deficiency disease | may prevent | MEDRT · Public domain (U.S. Government work) |
| Cystic fibrosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Heart failure | may treat | MEDRT · Public domain (U.S. Government work) |
| Hypertensive disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Potassium deficiency disease | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.