Amitriptyline

Definition

A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.

Also known as AMITRIPTYLINE — per NCIT

Also identified as

• ATC N06AA09 per RXNORM
• NCIT NCIT:C62005 per NCIT
• SCTID 372726002 per RXNORM
• SCTID 40589005 per RXNORM
• UNII 1806D8D52K per RXNORM

Indications