Amoxapine

Definition

A tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.

Also known as AMOXAPINE, Asendin, Demolox, Dibenz(b,f)(1,4)oxazepine, 2-Chloro-11-(1-piperazinyl)- — per NCIT

Also identified as

• ATC N06AA17 per RXNORM
• NCIT NCIT:C47397 per NCIT
• SCTID 29840005 per RXNORM
• SCTID 373754002 per RXNORM
• UNII R63VQ857OT per RXNORM

Indications