Azacitidine

Definition

A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04)

NCIT:C288 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one, 5 AZC, 5-AC, 5-Aza-cytidine, 5-Azacitidine, 5-Azacytidine, 5-AZC, AZACITIDINE, Azacytidine, Azacytidine, 5-, Ladakamycin, Mylosar, U-18496, Vidaza — per NCIT

Also identified as

ATC L01BC07 per RXNORM
NCIT NCIT:C288 per NCIT
SCTID 412328000 per RXNORM
SCTID 412329008 per RXNORM
UNII M801H13NRU per RXNORM

Indications

Disease	Relation	Source
Chronic myelomonocytic leukemia	may treat	MEDRT · Public domain (U.S. Government work)
Myelodysplastic syndrome with single lineage dysplasia	may treat	MEDRT · Public domain (U.S. Government work)
Sideroblastic anemia	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Bone marrow	may treat a disease of this organ	DERIVED · CC BY 4.0

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.