Aztreonam
Aztreonam
Definition
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.
Also known as Azactam, AZTREONAM, SQ 26,776 — per NCIT
Also identified as
- ATC J01DF01 per RXNORM
- NCIT NCIT:C28845 per NCIT
- SCTID 387386004 per RXNORM
- SCTID 69918003 per RXNORM
- UNII G2B4VE5GH8 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Cellulitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Endometritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Pseudomonas infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Respiratory tract infectious disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary tract infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Body of uterus | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Female reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Uterus | may treat a disease of this organ | DERIVED · CC BY 4.0 |
5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.