Cefazolin
Cefazolin
Definition
A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Also known as (6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, CEFAZOLIN — per NCIT
Also identified as
- ATC J01DB04 per RXNORM
- NCIT NCIT:C28913 per NCIT
- SCTID 387470007 per RXNORM
- SCTID 81088002 per RXNORM
- UNII IHS69L0Y4T per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bacterial endocarditis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Bacterial endocarditis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bacterial pneumonia | may treat | MEDRT · Public domain (U.S. Government work) |
| Escherichia coli infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Klebsiella infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Proteus infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Skin disease caused by bacterial infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Staphylococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Streptococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary tract infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Endocardium | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.