Chlorpromazine
ATC Code
N05AA01
Chlorpromazine
Definition
A phenothiazine and traditional antipsychotic agent with anti-emetic activity. Chlorpromazine exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, such as hallucinations and delusions. Chlorpromazine appears to exert its anti-emetic activity by blocking the dopamine receptors in the chemical trigger zone (CTZ) in the brain, thereby relieving nausea and vomiting.
Also known as 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine, Chlor-PZ, CHLORPROMAZINE, Thorazine — per NCIT
Also identified as
- ATC N05AA01 per RXNORM
- NCIT NCIT:C367 per NCIT
- SCTID 387258005 per RXNORM
- SCTID 47331002 per RXNORM
- UNII U42B7VYA4P per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Acute intermittent porphyria | may treat | MEDRT · Public domain (U.S. Government work) |
| Anxiety disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Oppositional defiant disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Tetanus | may treat | MEDRT · Public domain (U.S. Government work) |