Cimetidine
Cimetidine
Definition
A histamine H(2)-receptor antagonist. Enhancing anti-tumor cell-mediated responses, cimetidine blocks histamine's ability to stimulate suppressor T lymphocyte activity and to inhibit natural killer (NK) cell activity and interleukin-2 production. Cimetidine also may inhibit tumor growth by suppressing histamine's growth-factor activity and blocking histamine-induced stimulation of vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor. (NCI04)
Also known as CIMETIDINE, Guanidine, N''-Cyano-N-Methyl-N'-(2-(((5-Methyl-1H-Imidazol-4-yl)Methyl)Thio)Ethyl)-, N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine, Tagamet — per NCIT
Also identified as
- ATC A02BA01 per RXNORM
- NCIT NCIT:C374 per NCIT
- SCTID 373541007 per RXNORM
- SCTID 83532008 per RXNORM
- UNII 80061L1WGD per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Duodenal ulcer | may prevent | MEDRT · Public domain (U.S. Government work) |
| Gastric ulcer | may prevent | MEDRT · Public domain (U.S. Government work) |
| Duodenal ulcer | may treat | MEDRT · Public domain (U.S. Government work) |
| Dyspepsia | may treat | MEDRT · Public domain (U.S. Government work) |
| Gastric ulcer | may treat | MEDRT · Public domain (U.S. Government work) |
| Gastroesophageal reflux disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Helicobacter pylori infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Peptic esophagitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Urticaria | may treat | MEDRT · Public domain (U.S. Government work) |
| Zollinger-Ellison syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Esophagus | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Small intestine | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Stomach | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Upper digestive tract | may treat a disease of this organ | DERIVED · CC BY 4.0 |
7 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.