Clobetasol
Clobetasol
Definition
A topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Upon topical administration, clobetasol binds to cytoplasmic glucocorticoid receptors (GRs) and activates GR-mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol induces phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2. This inhibits skin inflammation, and reduces swelling, redness, itching and rashes.
Also known as CLOBETASOL — per NCIT
Also identified as
- ATC D07AD01 per RXNORM
- ATC S01BA17 per RXNORM
- NCIT NCIT:C65339 per NCIT
- SCTID 419129004 per RXNORM
- SCTID 48614001 per RXNORM
- UNII ADN79D536H per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Dermatitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Facial dermatosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Hand dermatosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Leg dermatosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Scalp dermatosis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.