Clonidine
Clonidine
Definition
An imidazoline derivate and centrally-acting alpha-adrenergic agonist, with antihypertensive activity. Clonidine binds to and stimulates central alpha-2 adrenergic receptors, thereby reducing the amount of norepinephrine (NE) release and thus decreasing sympathetic outflow to the heart, kidneys, and peripheral vasculature. The reduction in sympathetic outflow leads to decreased peripheral vascular resistance, decreased blood pressure, and decreased heart rate. In addition, clonidine binds to imidazoline receptor subtype 1 (I1), which may also contribute to a reduction in blood pressure.
Also known as Catapres-TTS, CLONIDINE, N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine — per NCIT
Also identified as
- ATC C02AC01 per RXNORM
- ATC N02CX02 per RXNORM
- ATC S01EA04 per RXNORM
- NCIT NCIT:C380 per NCIT
- SCTID 372805007 per RXNORM
- SCTID 62782004 per RXNORM
- UNII MN3L5RMN02 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Attention deficit hyperactivity disorder, inattentive type | may treat | MEDRT · Public domain (U.S. Government work) |
| Diarrheal disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Glaucoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Hypertensive disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Opiate dependence | may treat | MEDRT · Public domain (U.S. Government work) |
| Substance withdrawal syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Tourette syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Camera-type eye | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.