Clotrimazole
Clotrimazole
Definition
A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis.
Also known as 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole, CLOT, CLOTRIMAZOLE, Gyne-Lotrimin, Lotrimin, Mycelex, Mycelex Troche — per NCIT
Also identified as
- ATC A01AB18 per RXNORM
- ATC D01AC01 per RXNORM
- ATC G01AF02 per RXNORM
- NCIT NCIT:C381 per NCIT
- SCTID 387325003 per RXNORM
- SCTID 5797005 per RXNORM
- UNII G07GZ97H65 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Oral candidiasis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Cutaneous candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Oral candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Tinea pedis | may treat | MEDRT · Public domain (U.S. Government work) |
| Vulvovaginal candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |