Dapsone

Definition

A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.

Also known as 1358F, 4,4'-Sulfonylbis[benzenamine], 4,4'-Sulfonylbisbenzamine, 4,4'-Sulfonylbisbenzeneamine, 4,4'-Sulfonyldianiline, Aczone, Avlosulfon, Bis(4-aminophenyl) sulfone, Bis(4-aminophenyl)sulfone, Croysulfone, DADPS, DAPSONE, DDS, Diphenasone, Disulone, Dumitone, Eporal, Novophone, Sulfona-MAE, Sulphadione, Undolac — per NCIT

Also identified as

• ATC D10AX05 per RXNORM
• ATC J04BA02 per RXNORM
• NCIT NCIT:C415 per NCIT
• SCTID 17308007 per RXNORM
• SCTID 387096002 per RXNORM
• UNII 8W5C518302 per RXNORM

Indications

Organ Effects

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.