Deferoxamine

Definition

An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)

Also known as 1-Amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(n-acetylhydroxylamino)-6,11,17,22-tetraazaheptaeicosane, DEFEROXAMINE, Desferoxamine B, Desferrioxamine, Desferrioxamine B, DFO-B, N-[5-[3-[(5-Aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]propionohydroxamic Acid, N'-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxybutanediamide — per NCIT

Also identified as

• ATC V03AC01 per RXNORM
• NCIT NCIT:C416 per NCIT
• SCTID 372825006 per RXNORM
• SCTID 70702006 per RXNORM
• UNII J06Y7MXW4D per RXNORM

Indications