Rare disease reference — Atlas Médico

Demeclocycline

Definition

A semi-synthetic, broad-spectrum naphthacene antibiotic produced by the bacterium Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.

NCIT:C47980 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide, DEMECLOCYCLINE — per NCIT

Also identified as

ATC D06AA01 per RXNORM
ATC J01AA01 per RXNORM
NCIT NCIT:C47980 per NCIT
SCTID 10324005 per RXNORM
SCTID 372779007 per RXNORM
SCTID 5737008 per RXNORM
UNII 5R5W9ICI6O per RXNORM

Indications

Disease	Relation	Source
Actinomycosis	may treat	MEDRT · Public domain (U.S. Government work)
Campylobacteriosis	may treat	MEDRT · Public domain (U.S. Government work)
Cholera	may treat	MEDRT · Public domain (U.S. Government work)
Clostridium infectious disease	may treat	MEDRT · Public domain (U.S. Government work)
Gonorrhea	may treat	MEDRT · Public domain (U.S. Government work)
Inappropriate ADH syndrome	may treat	MEDRT · Public domain (U.S. Government work)
Lymphogranuloma venereum	may treat	MEDRT · Public domain (U.S. Government work)
Mycoplasma pneumoniae pneumonia	may treat	MEDRT · Public domain (U.S. Government work)
Ornithosis	may treat	MEDRT · Public domain (U.S. Government work)
Pertussis	may treat	MEDRT · Public domain (U.S. Government work)
Plague	may treat	MEDRT · Public domain (U.S. Government work)
Rocky mountain spotted fever	may treat	MEDRT · Public domain (U.S. Government work)
Trachoma	may treat	MEDRT · Public domain (U.S. Government work)
Typhoid fever	may treat	MEDRT · Public domain (U.S. Government work)
Urinary tract infection	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Lungs	may treat a disease of this organ	DERIVED · CC BY 4.0
Respiratory system	may treat a disease of this organ	DERIVED · CC BY 4.0

2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.