Desipramine
ATC Code
N06AA01
Desipramine
Definition
An active metabolite of imipramine, a tertiary amine and a synthetic tricyclic derivative of the antidepressant. Desipramine enhances monoamine neurotransmission in certain areas of the brain by inhibiting the re-uptake of noradrenaline and serotonin at the noradrenergic and serotoninergic nerve endings, respectively. It also induces sedation through histamine 1 receptor blockage and hypotension through beta-adrenergic blockage.
Also known as DESIPRAMINE — per NCIT
Also identified as
- ATC N06AA01 per RXNORM
- NCIT NCIT:C61700 per NCIT
- SCTID 33378002 per RXNORM
- SCTID 372705002 per RXNORM
- UNII TG537D343B per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Attention deficit hyperactivity disorder, inattentive type | may treat | MEDRT · Public domain (U.S. Government work) |
| Depressive disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Substance-related disorder | may treat | MEDRT · Public domain (U.S. Government work) |