Desonide

Definition

A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Also known as Desonate, DESONIDE, Verdeso — per NCIT

Also identified as

• ATC D07AB08 per RXNORM
• ATC S01BA11 per RXNORM
• NCIT NCIT:C61702 per NCIT
• SCTID 412363005 per RXNORM
• SCTID 52215008 per RXNORM
• UNII J280872D1O per RXNORM

Indications