Diazoxide

Definition

A benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release by interacting with ATP-sensitive potassium channels of pancreatic islet beta-cells.

Also known as 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide, DIAZOXIDE, Proglycem, SRG-95213 — per NCIT

Also identified as

• ATC C02DA01 per RXNORM
• ATC V03AH01 per RXNORM
• NCIT NCIT:C428 per NCIT
• SCTID 387328001 per RXNORM
• SCTID 58905004 per RXNORM
• UNII O5CB12L4FN per RXNORM

Indications