Diflunisal
Diflunisal
Definition
A difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. Diflunisal competitively inhibits both cyclooxygenase (COX) -1 and -2, with higher affinity for COX-1, and subsequently blocks the conversion of arachidonic acid to prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. Diflunisal differs from other salicylates, in that it is not metabolized to salicylic acid, hence it has a longer half-life.
Also known as (1,1'-Biphenyl)-3-carboxylic Acid, 2',4'-difluoro-4-hydroxy-, 2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic Acid, Apo-Diflunisal, DIFLUNISAL, Dolobid, Flovacil, Novo-Diflunisal, Nu-Diflunisal — per NCIT
Also identified as
- ATC N02BA11 per RXNORM
- NCIT NCIT:C47489 per NCIT
- SCTID 20865003 per RXNORM
- SCTID 387116004 per RXNORM
- UNII 7C546U4DEN per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Osteoarthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.