Dinoprostone

Definition

A synthetic prostaglandin E2 (PGE2) analogue with smooth muscle contraction inducing property. It has been suggested that PGE2 regulates the intracellular levels of cyclic 3, 5-adenosine monophosphate (cAMP) by activating adenylate cyclase and thereby increases cellular membrane calcium ion transport. By acting directly on the myometrium, dinoprostone induces uterine and gastrointestinal smooth muscle contractions.

Also known as Cervidil, Dinoglandin, DINOPROSTONE, Enzaprost E, Minprostin E2, Prepidil, Prostin E2 — per NCIT

Also identified as

• ATC G02AD02 per RXNORM
• NCIT NCIT:C61727 per NCIT
• SCTID 387245009 per RXNORM
• SCTID 44798001 per RXNORM
• UNII K7Q1JQR04M per RXNORM

Indications