Disulfiram

Disulfiram

Definition

An orally bioavailable carbamoyl derivative and a proteasome inhibitor that is used in the treatment of alcoholism, with potential antineoplastic and chemosensitizing activities. Disulfiram (DSF) may help to treat alcoholism by irreversibly binding to and inhibiting acetaldehyde dehydrogenase, an enzyme that oxidizes the ethanol metabolite acetaldehyde into acetic acid. Inhibition of acetaldehyde dehydrogenase leads to an accumulation of acetaldehyde and produces a variety of very unpleasant symptoms, which together are referred to as the disulfiram-ethanol reaction (DER). In addition, DSF has a strong ability to chelate metals and its antineoplastic activity is highly dependent upon binding to copper (Cu), a metal that selectively accumulates in cancer cells. DSF/Cu generates reactive oxygen species (ROS) and inhibits proteasome activity, leading to an accumulation of ubiquitinated proteins; both of these processes result in induction of apoptosis. Also, DSF/Cu inhibits various cancer-specific pathways, which leads to inhibition of tumor cell growth.

Also known as Antabuse, Bis(diethylthiocarbamoyl) Disulfide, DISULFIRAM, DS, Tetraethylthioperoxydicarbonic Diamide, Tetraethylthiuram Disulfide, Teturamin, TTD — per NCIT

Also identified as

Indications

Disease Relation Source
Alcohol abuse may prevent MEDRT · Public domain (U.S. Government work)
Alcohol abuse may treat MEDRT · Public domain (U.S. Government work)