Doxepin
Doxepin
Definition
A dibenzoxepin derivative and tricyclic antidepressant (TCA) with antipruritic, antidepressive and anxiolytic activities. Doxepin blocks the reuptake of norepinephrine and serotonin (5-HT) into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their neurotransmission. Doxepin also has antagonistic effects on histamine H1, 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is mediated through inhibition of histamine receptors.
Also known as DOXEPIN, Silenor — per NCIT
Also identified as
- ATC D04AX01 per RXNORM
- ATC N06AA12 per RXNORM
- NCIT NCIT:C65475 per NCIT
- SCTID 11841005 per RXNORM
- SCTID 372587005 per RXNORM
- UNII 5ASJ6HUZ7D per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Anxiety disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Atopic eczema | may treat | MEDRT · Public domain (U.S. Government work) |
| Depressive disorder | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.