Econazole
Econazole
Definition
An imidazole with antifungal property. Econazole compromises the integrity of fungal cell wall through inhibiting 14-alpha demethylase, which catalyzes conversion of lanosterol to ergosterol, an essential component of the fungal cell wall. As a result, this agent increases cellular permeability thereby resulting in leakage of cellular contents. Furthermore, econazole has also been implicated to inhibit endogenous respiration, interact with membrane phospholipids, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Also known as ECONAZOLE — per NCIT
Also identified as
- ATC D01AC03 per RXNORM
- ATC G01AF05 per RXNORM
- NCIT NCIT:C61740 per NCIT
- SCTID 18952006 per RXNORM
- SCTID 373471002 per RXNORM
- UNII 6Z1Y2V4A7M per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Cutaneous candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Pityriasis versicolor | may treat | MEDRT · Public domain (U.S. Government work) |
| Tinea pedis | may treat | MEDRT · Public domain (U.S. Government work) |