Enalaprilat
Enalaprilat
Definition
The active metabolite of the pro-drug enalapril, a dicarboxylate-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Enalaprilat prevents the conversion of angiotensin I into angiotensin II by inhibiting ACE, thereby leading to decreased vasopressor activity and resulting in vasodilation. This agent also decreases aldosterone secretion by the adrenal cortex, which leads to an increase in natriuresis.
Also known as Enalaprilat, ENALAPRILAT DIHYDRATE, N-(1(S)-Carboxy-3-phenylpropyl)-L-alanyl-L-proline — per NCIT
Also identified as
- NCIT NCIT:C47510 per NCIT
- SCTID 414092003 per RXNORM
- SCTID 48052001 per RXNORM
- UNII GV0O7ES0R3 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Diabetic kidney disease | may prevent | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may prevent | MEDRT · Public domain (U.S. Government work) |
| Bartter syndrome | may treat | MEDRT · Public domain (U.S. Government work) |
| Diabetic kidney disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Heart failure | may treat | MEDRT · Public domain (U.S. Government work) |
| Malignant hypertension | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Adult mammalian kidney | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Renal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
8 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.