Epirubicin

Definition

A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.

Also known as (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, 3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside, 4'-epi DX, 4'-Epiadriamycin, 4'-Epidoxorubicin, Epi DX, Epidoxorubicin, EPIRUBICIN, Pidorubicin — per NCIT

Also identified as

• ATC L01DB03 per RXNORM
• NCIT NCIT:C62028 per NCIT
• SCTID 349848009 per RXNORM
• SCTID 417916005 per RXNORM
• UNII 3Z8479ZZ5X per RXNORM

Indications