Estazolam

Definition

A triazolo-benzodiazepine with anxiolytic, anticonvulsant, hypnotic, and muscle relaxant properties. Estazolam binds to the gamma-aminobutyric acid (GABA) receptor at a site distinct from the inhibitory neurotransmitter GABA binding site in the limbic system of the central nervous system (CNS). This binding leads to an opening of the chloride channels, which allows the flow of chloride ions into the neuron, hyperpolarizes the neuronal membrane, inhibits neuronal firing, and leads to a decrease in neuronal excitability.

Also known as 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine, Esilgan, ESTAZOLAM, ProSom — per NCIT

Also identified as

• ATC N05CD04 per RXNORM
• NCIT NCIT:C47520 per NCIT
• SCTID 371364001 per RXNORM
• SCTID 96235001 per RXNORM
• UNII 36S3EQV54C per RXNORM

Indications