Flucytosine
Flucytosine
Definition
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.
Also known as 4-Amino-5-fluoro-2(1H)-pyrimidinone, 5-FC, 5-Fluorocytosine, Alcobon, Ancobon, Ancotil, FLUCYTOSINE, Ro 2-9915, Ro-2-9915 — per NCIT
Also identified as
- ATC D01AE21 per RXNORM
- ATC J02AX01 per RXNORM
- NCIT NCIT:C501 per NCIT
- SCTID 28506006 per RXNORM
- SCTID 387155003 per RXNORM
- UNII D83282DT06 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Aspergillosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Candidiasis | may treat | MEDRT · Public domain (U.S. Government work) |
| Chromomycosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Cryptococcal meningitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Meninx | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.