Floxuridine

Definition

A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)

Also known as 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil, 2-Deoxy-5-fluorouridine, 2'-Deoxy-5-fluorouridine, 5-Fluoro-2'-deoxy-beta-uridine, 5-Fluoro-2'-deoxyuridine, 5-Fluorodeoxyuridine, 5-Fluorouracil Deoxyriboside, 5-Fluorouridine Deoxyribose, 5-FUDR, FDUR, Floxuridin, FLOXURIDINE, Fluorodeoxyuridine, Fluorouridine Deoxyribose, Fluoruridine Deoxyribose, FUDR, WR 138720, WR-138720, WR138720 — per NCIT

Also identified as

• ATC L01BC09 per RXNORM
• NCIT NCIT:C504 per NCIT
• SCTID 387432008 per RXNORM
• SCTID 75927008 per RXNORM
• UNII 039LU44I5M per RXNORM

Indications