Flurbiprofen
Flurbiprofen
Definition
A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure.
Also known as 2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid, Ansaid, BTS 18,322, FLURBIPROFEN, U-27,182 — per NCIT
Also identified as
- ATC M01AE09 per RXNORM
- ATC M02AA19 per RXNORM
- ATC R02AX01 per RXNORM
- ATC S01BC04 per RXNORM
- NCIT NCIT:C508 per NCIT
- SCTID 373506008 per RXNORM
- SCTID 54344006 per RXNORM
- UNII 5GRO578KLP per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Osteoarthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.