Flutamide

Definition

A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)

Also known as 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, 4'-Nitro-3'-trifluoromethylisobutyranilide, Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide, Apimid, Cebatrol, Chimax, Cytomid, Drogenil, Euflex, Eulexin, Eulexine, Flucinom, Flucinome, Flugerel, Fluken, Flulem, FLUT, Fluta-Gry, Flutabene, Flutacan, Flutamex, FLUTAMIDE, Flutamin, Flutan, Flutaplex, Fugerel, Grisetin, Niftolide, Oncosal, Profamid, Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-, Prostacur, Prostadirex, Prostica, Prostogenat, SCH 13521, Tafenil, Tecnoflut, Testotard — per NCIT

Also identified as

• ATC L02BB01 per RXNORM
• NCIT NCIT:C509 per NCIT
• SCTID 387587007 per RXNORM
• SCTID 96371003 per RXNORM
• UNII 76W6J0943E per RXNORM

Indications