Fosfomycin
Fosfomycin
Definition
A phosphoenolpyruvate analogue and a synthetic broad-spectrum antibiotic with antimicrobial and bactericidal properties. Fosfomycin binds to and inactivates the enzyme enolpyruvate transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis and bacterial cell death.
Also known as FOSFOMYCIN — per NCIT
Also identified as
- ATC J01XX01 per RXNORM
- ATC S02AA17 per RXNORM
- NCIT NCIT:C61772 per NCIT
- SCTID 108720006 per RXNORM
- SCTID 372534005 per RXNORM
- UNII 2N81MY12TE per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Escherichia coli infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Gram-positive bacterial infections | may treat | MEDRT · Public domain (U.S. Government work) |
| Klebsiella infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Proteus infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Pyelonephritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary tract infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Adult mammalian kidney | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Renal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.