Guaifenesin
Guaifenesin
Definition
A glyceryl guaiacolate with expectorant effects. Guaifenesin increases respiratory tract mucus secretions, acts as an irritant to gastric vagal receptors and recruits efferent parasympathetic reflexes that cause glandular exocytosis. This agent reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus. Guaifenesin promotes the efficiency of the mucociliary mechanism important in removing accumulated secretions from the upper and lower airway.
Also known as 3-(o-Methoxyphenoxy)-1,2-propanediol, Glyceryl Guaiacolate, GUAIFENESIN, Humibid, Mucinex — per NCIT
Also identified as
- ATC R05CA03 per RXNORM
- NCIT NCIT:C29081 per NCIT
- SCTID 386184000 per RXNORM
- SCTID 87174009 per RXNORM
- UNII 495W7451VQ per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bronchitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Common cold | may treat | MEDRT · Public domain (U.S. Government work) |
| Laryngitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Perennial allergic rhinitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Pertussis | may treat | MEDRT · Public domain (U.S. Government work) |
| Pharyngitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Sinusitis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Chordate pharynx | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Craniocervical region | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Larynx | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nasal cavity | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nasopharynx | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Neck | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
8 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.