Hydrocodone

Definition

A semisynthetic hydrogenated codeine derivative and opioid agonist with analgesic and antitussive effects. Hydrocodone primarily binds to and activates the mu-opioid receptor in the central nervous system (CNS). This leads to analgesia, euphoria, respiratory depression, miosis, decreased gastrointestinal motility, cough suppression and physical dependence. Hydrocodone is converted to hydromorphone by the cytochrome P450 enzyme CYP2D6.

Also known as HYDROCODONE — per NCIT

Also identified as

• ATC R05DA03 per RXNORM
• NCIT NCIT:C62033 per NCIT
• SCTID 20320002 per RXNORM
• SCTID 372671002 per RXNORM
• UNII 6YKS4Y3WQ7 per RXNORM

Indications