Hydroxyzine
ATC Code
N05BB01
Hydroxyzine
Definition
A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine's antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
Also known as HYDROXYZINE — per NCIT
Also identified as
- ATC N05BB01 per RXNORM
- NCIT NCIT:C29103 per NCIT
- SCTID 372856003 per RXNORM
- SCTID 80165005 per RXNORM
- UNII 30S50YM8OG per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Anxiety disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Substance withdrawal syndrome | may treat | MEDRT · Public domain (U.S. Government work) |