Imipenem
Imipenem
Definition
A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. (NCI05)
Also known as 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid, 6-(1-Hydroxyethyl)-3-((2-((iminomethyl)amino)ethyl)thio)-7-oxo-, Monohydrate, (5R-(5alpha,6alpha(R*)))-, Imipemide, IMIPENEM, MK-0787 — per NCIT
Also identified as
- NCIT NCIT:C570 per NCIT
- SCTID 424285002 per RXNORM
- SCTID 46558003 per RXNORM
- UNII 71OTZ9ZE0A per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Bacterial infectious disease | may prevent | MEDRT · Public domain (U.S. Government work) |
| Bacterial endocarditis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bacterial infectious disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Pseudomonas infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Respiratory tract infectious disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Staphylococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Streptococcal infection | may treat | MEDRT · Public domain (U.S. Government work) |
| Urinary tract infection | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Endocardium | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.