Indapamide

Definition

An indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifier potassium channels, thereby blocking both slow and rapid K+ (IKs and IKr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (Ca++, Na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin E2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes.

NCIT:C29119 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as INDAPAMIDE, Lozol — per NCIT

Also identified as

ATC C03BA11 per RXNORM
NCIT NCIT:C29119 per NCIT
SCTID 387419003 per RXNORM
SCTID 74213004 per RXNORM
UNII F089I0511L per RXNORM

Indications

Disease	Relation	Source
Heart failure	may treat	MEDRT · Public domain (U.S. Government work)
Hypertensive disorder	may treat	MEDRT · Public domain (U.S. Government work)
Nephrotic syndrome	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Adult mammalian kidney	may treat a disease of this organ	DERIVED · CC BY 4.0
Cardiovascular system	may treat a disease of this organ	DERIVED · CC BY 4.0
Genitourinary system	may treat a disease of this organ	DERIVED · CC BY 4.0
Heart	may treat a disease of this organ	DERIVED · CC BY 4.0
Renal system	may treat a disease of this organ	DERIVED · CC BY 4.0

5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.