Indomethacin
Indomethacin
Definition
A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. (NCI04)
Also known as 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid, Indocin, Indometacin, INDOMETHACIN — per NCIT
Also identified as
- ATC C01EB03 per RXNORM
- ATC M01AB01 per RXNORM
- ATC M02AA23 per RXNORM
- ATC S01BC01 per RXNORM
- NCIT NCIT:C576 per NCIT
- SCTID 373513008 per RXNORM
- SCTID 60149003 per RXNORM
- UNII XXE1CET956 per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Ankylosing spondylitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Bursitis | may treat | MEDRT · Public domain (U.S. Government work) |
| Disease of the tendon | may treat | MEDRT · Public domain (U.S. Government work) |
| Osteoarthritis | may treat | MEDRT · Public domain (U.S. Government work) |
| Patent ductus arteriosus | may treat | MEDRT · Public domain (U.S. Government work) |
| Rheumatoid arthritis | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone element | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Musculoskeletal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skeletal joint | may treat a disease of this organ | DERIVED · CC BY 4.0 |
3 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.