Isocarboxazid

Definition

A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05)

Also known as 3-Isoxazolecarboxylic Acid, 5-methyl-, 2-(phenylmethyl)hydrazide, ISOCARBOXAZID, Marplan, Ro 5-0831 — per NCIT

Also identified as

• ATC N06AF01 per RXNORM
• NCIT NCIT:C47573 per NCIT
• SCTID 29877002 per RXNORM
• SCTID 387161000 per RXNORM
• UNII 34237V843T per RXNORM

Indications