Isotretinoin
Isotretinoin
Definition
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
Also known as 13-cis retinoic acid, 13-cis-Retinoate, 13-cis-Retinoic Acid, 13-cis-Vitamin A Acid, 13-cRA, 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid, Absorica, Accure, Accutane, Amnesteem, cis-Retinoic Acid, Cistane, Claravis, ISOTRETINOIN, Isotretinoinum, Isotrex, Isotrexin, Myorisan, Neovitamin A, Neovitamin A Acid, Oratane, Retinoicacid-13-cis, Ro 4-3780, Ro-4-3780, Roaccutan, Roaccutane, Roacutan, Sotret, ZENATANE — per NCIT
Also identified as
- ATC D10AD04 per RXNORM
- ATC D10BA01 per RXNORM
- NCIT NCIT:C603 per NCIT
- SCTID 38314008 per RXNORM
- SCTID 387208003 per RXNORM
- UNII EH28UP18IF per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Neuroblastoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.