Malathion

Definition

A synthetic phosphorous compound and cholinesterase inhibitor that is strictly used as a topical pediculicide. Malathion exerts its action on the nervous system of the lice by irreversibly inhibiting the activity of cholinesterase, thereby allowing acetylcholine to accumulate at cholinergic synapses and enhancing cholinergic receptor stimulation. This eventually leads to the head lice's death.

Also known as Butanedioic Acid,((dimethoxyphosphinothioyl)thio)-, Diethyl Ester, MALATHION, Ovide, Succinic Acid, mercapto-, Diethyl Ester, S-ester with O,O-Dimethylphosphorodithioate — per NCIT

Also identified as

• ATC P03AX03 per RXNORM
• NCIT NCIT:C47593 per NCIT
• SCTID 333071000 per RXNORM
• SCTID 87205003 per RXNORM
• UNII U5N7SU872W per RXNORM

Indications