Mannitol
Mannitol
Definition
A naturally occurring alcohol found in fruits and vegetables and used as an osmotic diuretic. Mannitol is freely filtered by the glomerulus and poorly reabsorbed from the renal tubule, thereby causing an increase in osmolarity of the glomerular filtrate. An increase in osmolarity limits tubular reabsorption of water and inhibits the renal tubular reabsorption of sodium, chloride, and other solutes, thereby promoting diuresis. In addition, mannitol elevates blood plasma osmolarity, resulting in enhanced flow of water from tissues into interstitial fluid and plasma.
Also known as D-Mannitol, MANNITOL, Mannitol, D-, Osmitrol, Resectisol — per NCIT
Also identified as
- ATC A06AD16 per RXNORM
- ATC B05BC01 per RXNORM
- ATC B05CX04 per RXNORM
- ATC R05CB16 per RXNORM
- ATC V04CX04 per RXNORM
- NCIT NCIT:C625 per NCIT
- SCTID 30761007 per RXNORM
- SCTID 387168006 per RXNORM
- UNII 3OWL53L36A per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Acute kidney injury | may prevent | MEDRT · Public domain (U.S. Government work) |
| Anuria | may prevent | MEDRT · Public domain (U.S. Government work) |
| Acute kidney injury | may treat | MEDRT · Public domain (U.S. Government work) |
| Anuria | may treat | MEDRT · Public domain (U.S. Government work) |
| Brain edema | may treat | MEDRT · Public domain (U.S. Government work) |
| Ocular hypertension | may treat | MEDRT · Public domain (U.S. Government work) |
| Prostate disorder | may treat | MEDRT · Public domain (U.S. Government work) |
| Pulmonary edema | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Adult mammalian kidney | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lungs | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Renal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Respiratory system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.