Mechlorethamine
Mechlorethamine
Definition
A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)
Also known as Bis(2-chloroethyl)methylamine, Chlorethazine, Chlormethine, chloromethine, ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl, HN 2, HN2, MECHLORETHAMINE, Methylbis(beta-chloroethyl)amine, methylchlorethamine, Mustard, Mustine, Nitrogen Mustard, NITROGEN MUSTARD HN-2 — per NCIT
Also identified as
- ATC L01AA05 per RXNORM
- NCIT NCIT:C62056 per NCIT
- SCTID 29156002 per RXNORM
- SCTID 372692002 per RXNORM
- SCTID 387071000 per RXNORM
- UNII 50D9XSG0VR per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Hodgkins lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Mycosis fungoides | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Skin of body | may treat a disease of this organ | DERIVED · CC BY 4.0 |
2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.