Meclizine

Definition

A synthetic piperazine with anti-emetic, sedative and histamine H1antagonistic properties. Meclizine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone.

Also known as 1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine, MECLIZINE, Meclozine — per NCIT

Also identified as

• ATC R06AE05 per RXNORM
• NCIT NCIT:C61610 per NCIT
• SCTID 372879002 per RXNORM
• SCTID 84951002 per RXNORM
• UNII 3L5TQ84570 per RXNORM

Indications