Medroxyprogesterone
Medroxyprogesterone
Definition
A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. (NCI04)
Also known as (6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione, 17Alpha-hydroxy-6alpha-methylprogesterone, 6Alpha-methyl-17alpha-hydroxyprogesterone, 6Alpha-methyl-4-pregnen-17alpha-ol-3,20-dione, Curretab, MEDROXYPROGESTERONE, Medroxyprogesterone acetate — per NCIT
Also identified as
- ATC G03AC06 per RXNORM
- ATC G03DA02 per RXNORM
- ATC L02AB02 per RXNORM
- NCIT NCIT:C629 per NCIT
- SCTID 126113007 per RXNORM
- SCTID 36621009 per RXNORM
- UNII HSU1C9YRES per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Amenorrhea | may treat | MEDRT · Public domain (U.S. Government work) |
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Endometrium neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Renal cell carcinoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Female reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Genitourinary system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Ovaries | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Reproductive system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.