Megestrol
Megestrol
Definition
A synthetic derivative of progesterone with antiestrogenic activity. Megestrol binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. In addition, megestrol stimulates appetite in cachectic subjects.
Also known as Compound 5071, MEG, MEGESTROL, Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl- — per NCIT
Also identified as
- ATC G03AC05 per RXNORM
- ATC G03DB02 per RXNORM
- ATC L02AB01 per RXNORM
- NCIT NCIT:C630 per NCIT
- SCTID 126091007 per RXNORM
- SCTID 38578004 per RXNORM
- UNII EA6LD1M70M per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Endometrium neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |