Methazolamide

Definition

A sulfonamide derivate and carbonic anhydrase inhibitor with potential antineoplastic activity. Methazolamide inhibits tumor-associated carbonic anhydrase IX (CAIX), which may result in increased cell death in hypoxic tumors. As a hypoxia-inducible transmembrane glycoprotein, CAIX catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, helping to maintain acidification of the tumor microenvironment and enhance resistance to cytotoxic therapy in some hypoxic tumors.

NCIT:C61318 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as Glauctabs, METHAZOLAMIDE, MZM, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-acetamide, Neptazane — per NCIT

Also identified as

ATC S01EC05 per RXNORM
NCIT NCIT:C61318 per NCIT
SCTID 392575007 per RXNORM
SCTID 53052005 per RXNORM
UNII W733B0S9SD per RXNORM

Indications

Disease	Relation	Source
Angle-closure glaucoma	may treat	MEDRT · Public domain (U.S. Government work)
Open-angle glaucoma	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Camera-type eye	may treat a disease of this organ	DERIVED · CC BY 4.0

1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.