Pioglitazone

Definition

An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.

NCIT:C71633 · NCI Thesaurus OBO Edition · CC BY 4.0

Also known as PIOGLITAZONE — per NCIT

Also identified as

ATC A10BD per NCIT
ATC A10BG per NCIT
NCIT NCIT:C71633 per NCIT

Indications

Disease	Relation	Source
Diabetes mellitus type 2	may treat	MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ	Side effect / interaction	Source
Alimentary part of gastrointestinal system	may treat a disease of this organ	DERIVED · CC BY 4.0
Pancreas	may treat a disease of this organ	DERIVED · CC BY 4.0

2 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.