Mexiletine
Mexiletine
Definition
A local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system.
Also known as 1-Methyl-2-(2,6-xylyloxy)ethylamine, 2-Propanamine, 1-(2,6-dimethylphenoxy)-, MEXILETINE, Mexiletinum — per NCIT
Also identified as
- ATC C01BB02 per RXNORM
- NCIT NCIT:C62047 per NCIT
- SCTID 372909002 per RXNORM
- SCTID 96298001 per RXNORM
- UNII 1U511HHV4Z per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Diabetic neuropathy | may treat | MEDRT · Public domain (U.S. Government work) |
| Ventricular fibrillation | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
1 entry above is marked DERIVED: Atlas Médico inferred it by combining two sourced claims, and no source asserts this link directly. Treat it as a navigation aid, not as a clinical statement.