Midazolam

Definition

A short-acting benzodiazepine derivative with an imidazole structure and with anxiolytic, amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam exerts its effect by binding to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS). This leads to an increase in the opening of chloride channels, membrane hyperpolarization and increases the inhibitory effect of GABA in the CNS. Midazolam may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft.

Also known as MIDAZOLAM — per NCIT

Also identified as

• ATC N05CD08 per RXNORM
• NCIT NCIT:C62049 per NCIT
• SCTID 26800000 per RXNORM
• SCTID 373476007 per RXNORM
• UNII R60L0SM5BC per RXNORM

Indications