Mitotane

Definition

A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)

Also known as (o,p)-DDD, 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene, 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane, 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane, 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane, 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane, 2, 4'-Dichlorodiphenyldichloroethane, 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane, 2,4'-Dichlorodiphenyldichloroethane, CB 313, CB-313, Chloditan, Chlodithane, DDD, Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-, Khloditan, Lisodren, Lysodren, MITOTANE, Mytotan, o,p' - DDD, o,p'-DDD, Ortho,para-DDD, WR-13045 — per NCIT

Also identified as

• ATC L01XX23 per RXNORM
• NCIT NCIT:C664 per NCIT
• SCTID 26288002 per RXNORM
• SCTID 404865004 per RXNORM
• UNII 78E4J5IB5J per RXNORM

Indications