Mitoxantrone
Mitoxantrone
Definition
An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.
Also known as 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione, 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone, Dihydroxyanthracenedione, MITOXANTRONE, Mitozantrone — per NCIT
Also identified as
- ATC L01DB07 per RXNORM
- NCIT NCIT:C62050 per NCIT
- SCTID 108791001 per RXNORM
- SCTID 386913001 per RXNORM
- UNII BZ114NVM5P per RXNORM
Indications
| Disease | Relation | Source |
|---|---|---|
| Acute myeloid leukemia | may treat | MEDRT · Public domain (U.S. Government work) |
| Breast neoplasm | may treat | MEDRT · Public domain (U.S. Government work) |
| Lymphoma | may treat | MEDRT · Public domain (U.S. Government work) |
| Multiple sclerosis | may treat | MEDRT · Public domain (U.S. Government work) |
| Prostate cancer | may treat | MEDRT · Public domain (U.S. Government work) |
| Sarcoma | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Bone marrow | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Central nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Lymphoid system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Nervous system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.